Ethanol affects NMDA receptor signaling at climbing fiber - 3 Purkinje cell synapses in mice and impairs cerebellar LTD
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1 2 Ethanol affects NMDA receptor signaling at climbing fiber 3 Purkinje cell synapses in mice and impairs cerebellar LTD 4 5 6 Qionger He, Heather Titley, Giorgio Grasselli, Claire Piochon 7 and Christian Hansel 8 9 Department of Neurobiology, University of Chicago, Chicago, Illinois, USA 10 11 12 13 14 15 16 Running head: Ethanol affects Purkinje cell NMDA receptors 17 18 Corresponding author: C. Hansel, University of Chicago, Dept. of Neurobiology, 947 19 E. 58 Street, J243, Chicago, IL, USA. E-mail: [email protected] 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 Articles in PresS. J Neurophysiol (December 5, 2012). doi:10.1152/jn.00350.2012
منابع مشابه
Ethanol affects NMDA receptor signaling at climbing fiber-Purkinje cell synapses in mice and impairs cerebellar LTD.
Ethanol profoundly influences cerebellar circuit function and motor control. It has recently been demonstrated that functional N-methyl-(D)-aspartate (NMDA) receptors are postsynaptically expressed at climbing fiber (CF) to Purkinje cell synapses in the adult cerebellum. Using whole cell patch-clamp recordings from mouse cerebellar slices, we examined whether ethanol can affect NMDA receptor si...
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Acute alcohol consumption causes deficits in motor coordination and gait, suggesting an involvement of cerebellar circuits, which play a role in the fine adjustment of movements and in motor learning. It has previously been shown that ethanol modulates inhibitory transmission in the cerebellum and affects synaptic transmission and plasticity at excitatory climbing fiber (CF) to Purkinje cell sy...
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A classic view in cerebellar physiology holds that Purkinje cells do not express functional NMDA receptors and that, therefore, postsynaptic NMDA receptors are not involved in the induction of long-term depression (LTD) at parallel fiber (PF) to Purkinje cell synapses. Recently, it has been demonstrated that functional NMDA receptors are postsynaptically expressed at climbing fiber (CF) to Purk...
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The physiology of climbing fiber signals in cerebellar Purkinje cells has been studied since the early days of electrophysiology. Both the climbing fiber-evoked complex spike and the role of climbing fiber activity in the induction of long-term depression (LTD) at parallel fiber-Purkinje cell synapses have become hallmark features of cerebellar physiology. However, the key role of climbing fibe...
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Glutamate receptor (GluR) delta2 selectively expressed in cerebellar Purkinje cells (PCs) plays key roles in long-term depression (LTD) induction at parallel fiber (PF)-PC synapses, motor learning, the matching and connection of PF-PC synapses in developing and adult cerebella, the elimination of multiple climbing fibers (CFs) during development, and the regulation of CF territory on PCs. Howev...
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تاریخ انتشار 2012